Despite Karlovic hitting 19 aces, his ground strokes let him down and the world no.116 Reynolds used his chances to claim a surprise win.
Wild card holder Kevin Aderson of South Africa booked his place in the second round by beating the Brazilian Joao Souza 6-3 6-4.
Anderson will face American Sam Querrey next.
Also through is Tatsumo Ito of Japan, who dismissed his fellow countryman Go Soeda 6-4 7-5.






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