Isner, who reached the Indian Wells Final last week, where he lost to Federer, will play Florian Mayer of Germany in the next round. Mayer defeated Ivan Dodig of Croatia 6-4 7-5.
Milos Raonic set up a third round encounter against the 2009 winner Murray. The Canadian dismissed the French qualifier Arnaud Clement 7-6 (7) 6-2.
Raonic is on top form this year, he has already won two titles (Chennai and San Jose).
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